Jieyu Zheng

Jieyu Zheng

PhD student in Neurobioloby, Caltech

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A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.

Pages

Posts

Future Blog Post

less than 1 minute read

Published:

This post will show up by default. To disable scheduling of future posts, edit config.yml and set future: false.

Blog Post number 4

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 3

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 2

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

Blog Post number 1

less than 1 minute read

Published:

This is a sample blog post. Lorem ipsum I can’t remember the rest of lorem ipsum and don’t have an internet connection right now. Testing testing testing this blog post. Blog posts are cool.

portfolio

Pasadena Wildlife

Published:

Wildlife photography in the grand Pasadena Area, including LA County Arboretum and Huntington Library

Caltech

Published:

Photos taken at Caltech

publications

Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury

Published in Stroke, 2017

After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.

Recommended citation: Jiang, L., Li, W., Mamtilahun, M., Song, Y., Ma, Y., Qu, M., Lu, Y., He, X., **Zheng, J.** . . . Wang, Y. (2017). Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury. Stroke, 48(12), 3375-3383. https://doi.org/10.1161/STROKEAHA.117.019017

High Fat Diet Exacerbates Capillary Stalling in Alzheimer’s Disease-related Pathology in the APP/PS1 Mice Model

Published in Alzheimer’s and Dementia, 2018

This is a conference processing. The main study was published here.

Recommended citation: Bracko, O., Cruz, J., K. Vinarcsik, L., Ali, M., Swallow, M., **Zheng, J.**, … Schaffer, C. (2018). High Fat Diet Exacerbates Capillary Stalling in Alzheimer's Disease-related Pathology in the APP/PS1 Mice Model. Alzheimer’s and Dementia, 14, P749–P750. https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2018.06.900

Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer’s Disease

Published in Alzheimer’s and Dementia, 2018

In this study we uncovered leukocyte adhesion in brain capillaries as a mechanism contributing to reduced CBF in AD mouse models and showed that blocking this adhesion leads to immediate cognitive benefits even in advanced stages of disease development.

Recommended citation: Bracko, O., Cruz, J., N. Njiru, B., Swallow, M., **Zheng, J.**, Ali, M., … Schaffer, C. (2018). Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer's Disease. Alzheimer’s and Dementia, 14, P651–P652. https://doi.org/10.1016/j.jalz.2018.06.2709

Life without Cortex

Published in In Prep, 2024

This work is co-first-authored with Dr. Zeynep Turan. Click the link for the abstract!

Recommended citation: **Zheng, J.**, Turan, Z., Pollak, D., and Meister, M. (In Prep). Life without Cortex

The Unbearable Slowness of Being

Published in arXIV, 2024

This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In comparison, our sensory systems gather data at an enormous rate, no less than 1 gigabits/s. The stark contrast between these numbers remains unexplained. Resolving this paradox should teach us something fundamental about brain function: What neural substrate sets this low speed limit on the pace of our existence? Why does the brain need billions of neurons to deal with 10 bits/s? Why can we only think about one thing at a time? In this article, we consider plausible explanations for the conundrum and are led to the problem of routing: The critical limit is not the neural machinery needed to process 10 bits/s for a given task, but the need to switch rapidly between thousands of tasks, and as often as several times a second. This requires a massive degree of flexible routing between sensory streams, motor streams, and the processors that connect them. We review prior proposals on the neural mechanisms of flexible routing and propose research directions to address the paradox between fast neurons and slow behavior.

Recommended citation: **Zheng, J.** and Meister, M. (2024). The Unbearable Slowness of Being

talks

teaching

BEE 2600 Principles of Biological Engineering

Undergraduate Course, Biological and Environmental Engineering, Cornell University, 2017

Instructor: Mingming Wu, Associate Professor of Department of Biological Engineering, Cornell University

CNS 187 Neural Computation

Graduate Course, Computation & Neural Systems, Caltech, 2022

Instructors: Markus Meister and Ueli Rutishauser, Professors of Computation and Neural Systems, Caltech