Jieyu Zheng

Jieyu Zheng

PhD student in Neurobioloby, Caltech

Publications

Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer’s Disease

Published in Alzheimer’s and Dementia, 2018

In this study we uncovered leukocyte adhesion in brain capillaries as a mechanism contributing to reduced CBF in AD mouse models and showed that blocking this adhesion leads to immediate cognitive benefits even in advanced stages of disease development.

Recommended citation: Bracko, O., Cruz, J., N. Njiru, B., Swallow, M., **Zheng, J.**, Ali, M., … Schaffer, C. (2018). Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer's Disease. Alzheimer’s and Dementia, 14, P651–P652. https://doi.org/10.1016/j.jalz.2018.06.2709

High Fat Diet Exacerbates Capillary Stalling in Alzheimer’s Disease-related Pathology in the APP/PS1 Mice Model

Published in Alzheimer’s and Dementia, 2018

This is a conference processing. The main study was published here.

Recommended citation: Bracko, O., Cruz, J., K. Vinarcsik, L., Ali, M., Swallow, M., **Zheng, J.**, … Schaffer, C. (2018). High Fat Diet Exacerbates Capillary Stalling in Alzheimer's Disease-related Pathology in the APP/PS1 Mice Model. Alzheimer’s and Dementia, 14, P749–P750. https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2018.06.900

Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury

Published in Stroke, 2017

After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.

Recommended citation: Jiang, L., Li, W., Mamtilahun, M., Song, Y., Ma, Y., Qu, M., Lu, Y., He, X., **Zheng, J.** . . . Wang, Y. (2017). Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury. Stroke, 48(12), 3375-3383. https://doi.org/10.1161/STROKEAHA.117.019017