Life and Cognition without Cortex
Published in In Prep, 2025
This work is co-first-authored with Dr. Zeynep Turan.
Recommended citation: **Zheng, J.**, Turan, Z., Sadorf, K., and Meister, M. (In Prep). Life without Cortex
Projects and Publications
The unbearable slowness of being: Why do we live at 10 bits/s?
Published in Neuron, 2024
A review on a major paradox of behavior and brain.
Recommended citation: **Zheng, J.** and Meister, M. (2024). The unbearable slowness of being: Why do we live at 10 bits/s? Neuron. https://doi.org/10.1016/j.neuron.2024.11.008
Mice in the Manhattan Maze: Rapid Learning, Flexible Routing and Generalization, With and Without Cortex
Published in , 2024
My main project, using a novel tool to study complex cognition in mice and the role of cortex!
Recommended citation: Zheng, J., Guimarães, R., Hu, J., Perona, P., and Meister, M. (In Prep). Mice in the Manhattan Maze: Rapid Learning, Flexible Routing and Generalization
Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer’s Disease
Published in Alzheimer’s and Dementia, 2018
In this study we uncovered leukocyte adhesion in brain capillaries as a mechanism contributing to reduced CBF in AD mouse models and showed that blocking this adhesion leads to immediate cognitive benefits even in advanced stages of disease development.
Recommended citation: Bracko, O., Cruz, J., N. Njiru, B., Swallow, M., **Zheng, J.**, Ali, M., … Schaffer, C. (2018). Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer's Disease. Alzheimer’s and Dementia, 14, P651–P652. https://doi.org/10.1016/j.jalz.2018.06.2709
High Fat Diet Exacerbates Capillary Stalling in Alzheimer’s Disease-related Pathology in the APP/PS1 Mice Model
Published in Alzheimer’s and Dementia, 2018
This is a conference processing. The main study was published here.
Recommended citation: Bracko, O., Cruz, J., K. Vinarcsik, L., Ali, M., Swallow, M., **Zheng, J.**, … Schaffer, C. (2018). High Fat Diet Exacerbates Capillary Stalling in Alzheimer's Disease-related Pathology in the APP/PS1 Mice Model. Alzheimer’s and Dementia, 14, P749–P750. https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2018.06.900
Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury
Published in Stroke, 2017
After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.
Recommended citation: Jiang, L., Li, W., Mamtilahun, M., Song, Y., Ma, Y., Qu, M., Lu, Y., He, X., **Zheng, J.** . . . Wang, Y. (2017). Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury. Stroke, 48(12), 3375-3383. https://doi.org/10.1161/STROKEAHA.117.019017