Projects and Publications

The Unbearable Slowness of Being

Published in arXIV, 2024

This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In comparison, our sensory systems gather data at an enormous rate, no less than 1 gigabits/s. The stark contrast between these numbers remains unexplained. Resolving this paradox should teach us something fundamental about brain function: What neural substrate sets this low speed limit on the pace of our existence? Why does the brain need billions of neurons to deal with 10 bits/s? Why can we only think about one thing at a time? In this article, we consider plausible explanations for the conundrum and are led to the problem of routing: The critical limit is not the neural machinery needed to process 10 bits/s for a given task, but the need to switch rapidly between thousands of tasks, and as often as several times a second. This requires a massive degree of flexible routing between sensory streams, motor streams, and the processors that connect them. We review prior proposals on the neural mechanisms of flexible routing and propose research directions to address the paradox between fast neurons and slow behavior.

Recommended citation: **Zheng, J.** and Meister, M. (2024). The Unbearable Slowness of Being

Life without Cortex

Published in In Prep, 2024

This work is co-first-authored with Dr. Zeynep Turan. Click the link for the abstract!

Recommended citation: **Zheng, J.**, Turan, Z., Pollak, D., and Meister, M. (In Prep). Life without Cortex

Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer’s Disease

Published in Alzheimer’s and Dementia, 2018

In this study we uncovered leukocyte adhesion in brain capillaries as a mechanism contributing to reduced CBF in AD mouse models and showed that blocking this adhesion leads to immediate cognitive benefits even in advanced stages of disease development.

Recommended citation: Bracko, O., Cruz, J., N. Njiru, B., Swallow, M., **Zheng, J.**, Ali, M., … Schaffer, C. (2018). Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer's Disease. Alzheimer’s and Dementia, 14, P651–P652. https://doi.org/10.1016/j.jalz.2018.06.2709

High Fat Diet Exacerbates Capillary Stalling in Alzheimer’s Disease-related Pathology in the APP/PS1 Mice Model

Published in Alzheimer’s and Dementia, 2018

This is a conference processing. The main study was published here.

Recommended citation: Bracko, O., Cruz, J., K. Vinarcsik, L., Ali, M., Swallow, M., **Zheng, J.**, … Schaffer, C. (2018). High Fat Diet Exacerbates Capillary Stalling in Alzheimer's Disease-related Pathology in the APP/PS1 Mice Model. Alzheimer’s and Dementia, 14, P749–P750. https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2018.06.900

Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury

Published in Stroke, 2017

After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.

Recommended citation: Jiang, L., Li, W., Mamtilahun, M., Song, Y., Ma, Y., Qu, M., Lu, Y., He, X., **Zheng, J.** . . . Wang, Y. (2017). Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury. Stroke, 48(12), 3375-3383. https://doi.org/10.1161/STROKEAHA.117.019017