Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer’s Disease
Published in Alzheimer’s and Dementia, 2018
Recommended citation: Bracko, O., Cruz, J., N. Njiru, B., Swallow, M., **Zheng, J.**, Ali, M., … Schaffer, C. (2018). Stalled Blood Flow in Brain Capillaries Is Responsible for Reduced Cortical Perfusion and Impacts Cognitive Function in Mouse Models of Alzheimer's Disease. Alzheimer’s and Dementia, 14, P651–P652. https://doi.org/10.1016/j.jalz.2018.06.2709
In this study we uncovered leukocyte adhesion in brain capillaries as a mechanism contributing to reduced CBF in AD mouse models and showed that blocking this adhesion leads to immediate cognitive benefits even in advanced stages of disease development.