Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury
Published in Stroke, 2017
Recommended citation: Jiang, L., Li, W., Mamtilahun, M., Song, Y., Ma, Y., Qu, M., Lu, Y., He, X., **Zheng, J.** . . . Wang, Y. (2017). Optogenetic Inhibition of Striatal GABAergic Neuronal Activity Improves Outcomes After Ischemic Brain Injury. Stroke, 48(12), 3375-3383. https://doi.org/10.1161/STROKEAHA.117.019017
After ischemic stroke, optogenetic inhibition of GABAergic neurons upregulated bFGF expression by endothelial cells and promoted neurobehavioral recovery, possibly orchestrated by astrocytes. Optogenetically inhibiting neuronal activity provides a novel approach to promote neurological recovery.